Jun 23, 2020 CD47 is an abundantly expressed transmembrane cell surface glycoprotein that can act as a receptor for thrombospondins, form complexes with

Jun 15, 2019 At the 24th Congress of the European Hematology Association (EHA), David Sallman from the Moffitt Cancer Center, Tampa, US, discusses if

Summary of CD47 (IAP, MER6, OA3) expression in human tissue. Cytoplasmic and membranous expression in several tissues. CD47 (IAP, MER6, OA3) protein expression summary. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occu rs upon cell adhesion to extracellular matrix. 2020-12-01 · Regulation of CD47 expression Cytokines.

Cd47 expression

Expression of CD47 (IAP, MER6, OA3) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. High CD47 expression is associated with the increase in the ability of surviving breast cancer cells to evade innate and adaptive immunity. CD47 expression is decreased on the surface of erythrocytes in obese subjects. Structure and Expression of CD47 in the Plasma Membrane CD47 (originally named integrin-associated protein (IAP)) is a cell surface protein of the immunoglobulin (Ig) superfamily, which is heavily glycosylated and expressed by virtually all cells in the body [ 1 cancer cells is the expression of CD47, a cell-surface protein that interacts with signal regulatory protein α on macrophages to block phagocytosis (15–17).

Cytoplasmic and membranous expression in a subset of tissues including brain, urinary bladder, prostate and fallopian tube. In summary, CD47 can function as a marker of self on both RBCs and platelets.

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CD47 interacts with several membrane integrins, most commonly integrin α V β 3. These interactions result in CD47/integrin complexes that affect a range of cell functions including adhesion, spreading and migration. Function Tumor cells.

factor alpha-Pal/NRF-1 is a critical regulator of the human IAP/CD47 gene. Alpha-pal / Nrf-1 in Neurons: Alpha-pal / Nrf-1 Regulates Iap/cd47 Expression

Correlation between CD47 expression and clinic-pathological parameters.

We have added this description in the revised manuscript (page 16, line 7). CD47 null VSMCs or WT VSMCs in which CD47 expression has been knocked down with an antisense morpholino are insensitive to TSP1 inhibition of NO-stimulated relaxation. 65. These results were found to have implications in vivo in several models of tissue injury. gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes.
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gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jul 2010) GeneCards Summary for CD47 Gene: CD47 (CD47 molecule) is a protein-coding gene.

9 –11 Furthermore, the magnitude of CD47 expression could be used as a prognostic marker for recurrence and metastasis in human breast cancer, 12 as well as the aggressiveness 2020-08-18 · High expression of CD47 in tissue-infiltrating NK cells and CD8+ T cells in EC patients can, therefore, affect the efficacy of anti-CD47 therapy in EC. Skip to main content Thank you for visiting The expression of CD47 in ATLL might be associated with hypoxia, HIF-1, or an aberration introduced by the tumor.
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Jun 15, 2019 At the 24th Congress of the European Hematology Association (EHA), David Sallman from the Moffitt Cancer Center, Tampa, US, discusses if

Cytoplasmic and membranous expression in a subset of tissues including brain, urinary bladder, prostate and fallopian tube. In summary, CD47 can function as a marker of self on both RBCs and platelets. The phagocytosis-inhibitory effect is dependent on the CD47 expression level, and CD47-SIRPα signaling acts locally in the macrophage at the contact with a target cell.

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Expression of CD47 (IAP, MER6, OA3) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

We also found that CD47 activated the inflammatory genes IL-6, IL-7 and MCP-1 by a NF-κB-dependent mechanism in human astrocytoma but not in normal astrocytes. CD47 mRNA level is not a poorly prognostic factor in gastric tumors [29]. More studies should be performed to elucidate the respective role(s) of CD47 in different cancer types so as to optimize potential anti-CD47 therapy. There are a few studies on CD47 expression in Pan-NETs. One report has suggested CD47 overexpression Enhanced expression of CD47 has also been reported in primary NSCLC tumors and cell lines .